Optimization of the preparation of fluorine-18-labeled steroid receptor ligands 16alpha-[18 F]fluoroestradiol (FES), [18 F]fluoro furanyl norprogesterone (FFNP), and 16beta-[18 F]fluoro-5alpha-dihydrotestosterone (FDHT) as radiopharmaceuticals
نویسندگان
چکیده
منابع مشابه
Chemistry of Fluorine- 18 Radiopharmaceuticals
The chemistry of lSF has the reputation of being difficult and this is to a large extent supported by a survey of the literature, where there are many reports of reactions involving 18F where the yields are low and the reactions erratic. However, in the nine years since the last review of the chemistry of ~8F in this journal °) considerable progress has been made in understanding and controllin...
متن کاملSynthesis of fluorine-18 labeled GABA uptake inhibitors.
The first syntheses of fluorine-18 labeled inhibitors of GABA reuptake [(R,S)-1-[2-[4-[18F]fluorophenyl]phenyl]methoxyethyl]piperidine- 3-carboxylic acid, (R,S)-1-[2-[(4-[18F]trifluoromethyl)phenyl][(4- trifluoromethyl)phenyl]-methoxyethyl]piperidine-3-carboxylic acid] are described. These N-substituted nipecotic acid derivatives were prepared in no-carrier-added form by the condensation of the...
متن کاملFluorine-18 Labeled Tracers for Pet Studies in the Neurosciences
Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any speci...
متن کاملFluorine-18 labeled amino acids for tumor PET/CT imaging
Tumor glucose metabolism and amino acid metabolism are usually enhanced, 18F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor...
متن کاملA18 18..18
The population prevalence of intellectual disability (also known as learning disability in UK health services) is approximately 1%, rather similar to the estimate of lifetime population risk for schizophrenia. The risk of psychiatric illness, particularly schizophrenia, is thought to be increased in people with intellectual disability. Morgan et al (pp. 364–372) linked two large population-base...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Labelled Compounds and Radiopharmaceuticals
سال: 2014
ISSN: 0362-4803
DOI: 10.1002/jlcr.3191